That's a good question.
Hmmm....
I'll list a few things that I would consider.
The first thing would be to keep in mind at all times how the situation may change in the future.
Next, combustibles in the vicinity of the doors, layout of those combustibles, height of the ceiling, wall linings/displays by the doors, distance apart of the doors of course, routes to those doors in the room, travel distances within the room, whether the doors lead to a single route on the other side (as has been stated), numbers of people, density of people, mobility of people. I probably wouldn't do any calcs though it's a possibility that ASET/RSET calcs could, if done properly, give a good insight. It's a qualitative thing more than a quantitative thing. Judgement.
But I'll come back to what I said - "that's a good question." You're right - this "judgement" has to be written down in a FRA and made apparent to others that follow. That's not easy if you're taking into account all the variables I've mentioned plus a bunch of others that you can add. So, in steps the 45 degree rule. Simplicity itself. Everyone can use it.
But it's not the whole picture.....
Stu