I have experience of designing these systems, the key aspect is the set up, they can be adjusted to suit virtually any environment, with programmable sensitivity levels. The key to success is good commissioing, correctly matched to suit the risk (often they are left at the factory settings, and have a reputation for false alarms). One Vesda unit can cover up to 2000m2 with 4 pipes, alternatively there is a scanner version of this product which gives you an output for each pipe, that way you can quickly identify which area is in alarm, rather than searching the entire zone.
As for the cause and effect well it depends on what the risk is? and the proccess and operations that are going on in the building.
If you can provide some additional information, then further advice can be added.
I hope this helps.
Gary Howe.