I assume you are referring to Deaf Alerter type systems. These are not fire alarm systems, they are radio paging systems which activate on a signal from the fire alarm and send signals to pagers carried by the deaf person. If that's what you are getting at, then yes, there is an enormous difference between them.
UHF systems rely on the radio signal being 'bounced' around a protected area. This means that a signal can be very strong in one area of a room, but almost negligible in another only a few meters away. Even moving a cabinet can have a significant effect on the singal being received by the pager. VHF singals tend to penetrate solid structures better, albeit over shorter distances.
The big difference comes over 5839 compliance. Firstly, the standard clearly states that such a system must require a licenced frequency. This ensures that the frequency it transmits on is dedicated to that particular purpose. Domestic type systems (pm me if you want some names) do not have this and seem to suggest it is some kind of advantage, as a radio licence costs money. Nevertheless, without this, the system does not comply with BS5839 - end of.
Secondly, any messaging, other than fire alarm messaging, which is carried on the system, has to be prioritised such that a fire message takes priority. Many such systems allow general paging messages to be sent via a computer programme. For instance, the deaf user may be sent a notification of a meeting or lecture room being changed. In order to comply with 5839, these MUST be overwritten by any fire alarm signal. Again, this precludes the use of many such systems (pm me, etc). The Scope system is only compliant if the messaging function is NOT used. The Scope manual actually says that using this function would negate compliance with 5839, although (surprisingly?) the sales literature doesn't.
Deaf Alerter meets all of these criteria, but may be overpriced and overspecified if you only want simple fire alarm warning. The Scope system may be adequate and would be much cheaper, although the quality is far lower (IMHO). Also, Deaf Alerter is the only system which allows the user to carry pagers between buildings on a site - a patented function called 'Roaming'. No other system should claim to be able to do this, as it would infringe patent.
Finally, Deaf Alerter will take responsibility for surveying the building and installing, commissioning, etc the system. Other systems are usually sold to and fitted by fire alarm companies or contractors with no specialist radio knowledge. But oh boy, do you pay for the expertise.
Pm me if etc. etc